Scilimati, Antonio : rechercher sur Z-Library

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1

Novel Synthesis of 3,4-Diarylisoxazole Analogues of Valdecoxib: Reversal Cyclooxygenase-2 Selectivity by Sulfonamide Group Removal

Di Nunno, Leonardo, Vitale, Paola, Scilimati, Antonio, Tacconelli, Stefania, Patrignani, Paola

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 158 KB

english, 2004

2

Impact of 68Ga-DOTATOC PET/CT in comparison to 111In-Octreotide SPECT/CT in management of neuro-endocrine tumors

Tolomeo, Anna, Lopopolo, Gaetano, Dimiccoli, Vincenzo, Perioli, Luana, Modoni, Sergio, Scilimati, Antonio

Journal:

Année:

2020

Fichier:

PDF, 617 KB

2020

3

Stereoselective Prostereogenic 3-Oxo Ester Reduction Mediated by a Novel Yeast Alcohol Dehydrogenase Derived from Kluyveromyces marxianus CBS 6556

Maria Grazia Perrone, Ernesto Santandrea, Antonio Scilimati, Christoph Syldatk

Journal:

Advanced Synthesis & Catalysis

Année:

2007

Langue:

english

Fichier:

PDF, 167 KB

english, 2007

4

ChemInform Abstract: Baker′s Yeast-Induced Asymmetric Reduction of α-Ketosulfides: Synthesis of Optically Active 1-(Benzothiazol-2-ylsulfanyl)-2-alkanols, 2-Alkanols, and Thiiranes.

Leonardo Di Nunno, Carlo Franchini, Angelo Nacci, Antonio Scilimati, Maria Stefania Sinicropi

Journal:

Année:

1999

Fichier:

PDF, 34 KB

1999

5

ChemInform Abstract: Chemical and Chemoenyzmatic Routes to 1-(Benzothiazol-2-ylsulfanyl)-3-chloropropan-2-ol, a Precursor of Drugs with Potential β-Blocker Activity.

Leonardo Di Nunno, Carlo Franchini, Antonio Scilimati, Maria Stefania Sinicropi, Paolo Tortorella

Journal:

Année:

2000

Fichier:

PDF, 31 KB

2000

6

ChemInform Abstract: Lipase-Mediated Kinetic Resolution of Rigid Clofibrate Analogues with Lipid-Modifying Activity.

Savina Ferorelli, Carlo Franchini, Fulvio Loiodice, Maria Grazia Perrone, Antonio Scilimati, Maria Stefania Sinicropi, Paolo Tortorella

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

7

ChemInform Abstract: Regioselective Synthesis and Side-Chain Metalation and Elaboration of 3-Aryl-5-alkylisoxazoles.

Leonardo Di Nunno, Antonio Scilimati, Paola Vitale

Journal:

Année:

2002

Fichier:

PDF, 29 KB

2002

8

Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARα Agonists.

Maria Grazia Perrone, Ernesto Santandrea, Natalina Dell'Uomo, Fabio Giannessi, Ferdinando Maria Milazzo, Anna Floriana Sciarroni, Antonio Scilimati, Vincenzo Tortorella

Journal:

Année:

2005

Fichier:

PDF, 25 KB

2005

9

ChemInform Abstract: A Novel Synthesis of N-Unsubstituted β-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines.

Paola Vitale, Leonardo Di Nunno, Antonio Scilimati

Journal:

Année:

2011

Fichier:

PDF, 27 KB

2011

10

Stereospecific synthesis and absolute configuration of mexiletine

Dr. Carlo Franchini, Carla Cellucci, Filomena Corbo, Giovanni Lentini, Antonio Scilimati, Vincenzo Tortorella, Francesca Stasi

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 526 KB

english, 1994

11

The Tertiary Amine Nitrogen Atom of Piperazine Sulfonamides as a Novel Determinant of Potent and Selective β3-Adrenoceptor Agonists

Maria Grazia Perrone, Laura Bleve, Ernesto Santandrea, Paola Vitale, Mauro Niso, Antonio Scilimati

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 582 KB

english, 2009

12

Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers

Marilena Muraglia, Carlo Franchini, Filomena Corbo, Antonio Scilimati, Vincenzo Tortorella, Maria Stefania Sinicropi, Annamaria De Luca, Michela De Bellis, Diana Conte Camerino

Journal:

Journal of Heterocyclic Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 361 KB

english, 2007

13

Palladium-catalysed synthesis of α-diallylated ketosulphides of benzothiazole and their transformation into diallyl thiiranes and trienes

Vincenzo Caló, Vito Fiandanese, Angelo Nacci, Antonio Scilimati

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 168 KB

english, 1995

14

A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of β3-adrenergic receptor agonists

Maria Grazia Perrone, Ernesto Santandrea, Erika Giorgio, Laura Bleve, Antonio Scilimati, Paolo Tortorella

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 150 KB

english, 2006

15

Stereospecific synthesis and bio-activity of novel β3-adrenoceptor agonists and inverse agonists

Maria Grazia Perrone, Ernesto Santandrea, Laura Bleve, Paola Vitale, Nicola Antonio Colabufo, Ralf Jockers, Ferdinando Maria Milazzo, Anna Floriana Sciarroni, Antonio Scilimati

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 315 KB

english, 2008

16

Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists

Maria Grazia Perrone, Ernesto Santandrea, Natalina Dell’Uomo, Fabio Giannessi, Ferdinando Maria Milazzo, Anna Floriana Sciarroni, Antonio Scilimati, Vincenzo Tortorella

Journal:

European Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 306 KB

english, 2005

17

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

Alessia Catalano, Alessia Carocci, Filomena Corbo, Carlo Franchini, Marilena Muraglia, Antonio Scilimati, Michela De Bellis, Annamaria De Luca, Diana Conte Camerino, Maria Stefania Sinicropi, Vincenzo

Journal:

European Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 203 KB

english, 2008

18

Reaction of 3-phenylisoxazole with alkyllithiums

Leonardo Di Nunno, Antonio Scilimati, Paola Vitale

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 330 KB

english, 2005

19

5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity

Leonardo Di Nunno, Antonio Scilimati, Paola Vitale

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 351 KB

english, 2005

20

Corrigendum to “5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity”: [Tetrahedron 61 (2005) 11270]

Leonardo Di Nunno, Antonio Scilimati, Paola Vitale

Journal:

Année:

2006

Fichier:

PDF, 37 KB

2006

21

Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides

Leonardo Di Nunno, Paola Vitale, Antonio Scilimati, Laura Simone, Francesco Capitelli

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 381 KB

english, 2007

22

Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA

Leonardo Di Nunno, Paola Vitale, Antonio Scilimati

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 290 KB

english, 2008

23

Baker’s yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARα ligands

Maria Grazia Perrone, Ernesto Santandrea, Antonio Scilimati, Vincenzo Tortorella, Francesco Capitelli, Valerio Bertolasi

Journal:

Tetrahedron: Asymmetry

Année:

2004

Langue:

english

Fichier:

PDF, 396 KB

english, 2004

24

Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues

Maria Grazia Perrone, Ernesto Santandrea, Antonio Scilimati, Christoph Syldatk, Vincenzo Tortorella

Journal:

Tetrahedron: Asymmetry

Année:

2005

Langue:

english

Fichier:

PDF, 130 KB

english, 2005

25

Chelation-controlled chemo-, regio- and enantio-selective synthesis of homoallylic alcohols

Vincenzo Caló, Vito Fiandanese, Angelo Nacci, Antonio Scilimati

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 630 KB

english, 1994

26

Regiocontrol by anchimeric co-ordination in the reactions of organocopper reagents with allylic substrates bearing two leaving groups. Synthesis of optically active homoallylic alcohols

Vincenzo Calò, Concetta De Nitti, Luigi Lopez, Antonio Scilimati

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 490 KB

english, 1992

27

Regioselective synthesis and side-chain metallation and elaboration of 3-aryl-5-alkylisoxazoles

Leonardo Di Nunno, Antonio Scilimati, Paola Vitale

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 107 KB

english, 2002

28

An efficient biocatalyzed kinetic resolution of methyl (Z)-3-arylsulphinylpropenoates

Cosimo Cardellicchio, Francesco Naso, Antonio Scilimati

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 363 KB

english, 1994

29

Optically active sulfoxides by enantiospecific reactions of bromovinyl aryl sulfoxides with grignard reagents

Cosimo Cardellicchio, Vito Fiandanese, Francesco Naso, Antonio Scilimati

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 248 KB

english, 1992

30

Chemical and chemoenzymatic routes to 1-(benzothiazol-2-ylsulfanyl)-3-chloropropan-2-ol, a precursor of drugs with potential β-blocker activity

Leonardo Di Nunno, Carlo Franchini, Antonio Scilimati, Maria Stefania Sinicropi, Paolo Tortorella

Journal:

Tetrahedron: Asymmetry

Année:

2000

Langue:

english

Fichier:

PDF, 287 KB

english, 2000

31

Lipase-mediated kinetic resolution of rigid clofibrate analogues with lipid-modifying activity

Savina Ferorelli, Carlo Franchini, Fulvio Loiodice, Maria Grazia Perrone, Antonio Scilimati, Maria Stefania Sinicropi, Paolo Tortorella

Journal:

Tetrahedron: Asymmetry

Année:

2001

Langue:

english

Fichier:

PDF, 165 KB

english, 2001

32

Baker's yeast-induced asymmetric reduction of α-ketosulfides: synthesis of optically active 1-(benzothiazol-2-ylsulfanyl)-2-alkanols, 2-alkanols, and thiiranes

Leonardo Di Nunno, Carlo Franchini, Angelo Nacci, Antonio Scilimati, Maria Stefania Sinicropi

Journal:

Tetrahedron: Asymmetry

Année:

1999

Langue:

english

Fichier:

PDF, 208 KB

english, 1999

33

Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides

Paola Vitale, Leonardo Di Nunno, Antonio Scilimati

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 650 KB

english, 2011

34

Diastereo- and enantioselective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts

Maria Grazia Perrone, Ernesto Santandrea, Antonio Scilimati, Christoph Syldatk, Vincenzo Tortorella, Francesco Capitelli, Valerio Bertolasi

Journal:

Tetrahedron: Asymmetry

Année:

2004

Langue:

english

Fichier:

PDF, 348 KB

english, 2004

35

Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues

Maria Grazia Perrone, Ernesto Santandrea, Leonardo Di Nunno, Antonio Scilimati, Vincenzo Tortorella, Francesco Capitelli, Valerio Bertolasi

Journal:

Tetrahedron: Asymmetry

Année:

2005

Langue:

english

Fichier:

PDF, 303 KB

english, 2005

36

A new synthesis of β-phenylaminothioesters and β-lactams via base-induced ring-opening of 2-phenyl-3-aryl-5-phenyl-thioisoxazolidines

Leonardo Di Nunno, Antonio Scilimati

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 689 KB

english, 1993

37

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo

Sophie Talon, Annamaria De Luca, Michela De Bellis, Jean-François Desaphy, Giovanni Lentini, Antonio Scilimati, Filomena Corbo, Carlo Franchini, Paolo Tortorella, Harald Jockusch, Diana Conte Camerino

Journal:

British Journal of Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 207 KB

english, 2001

38

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

Dr. Maria Grazia Perrone, Dr. Paola Vitale, Dr. Paola Malerba, Dr. Angela Altomare, Dr. Rosanna Rizzi, Prof. Antonio Lavecchia, Dr. Carmen Di Giovanni, Prof. Ettore Novellino, Prof. Antonio Scilimati

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 744 KB

english, 2012

39

Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalysts for ketone reductions

Paola Vitale, Filippo Maria Perna, Maria Grazia Perrone, Antonio Scilimati

Journal:

Tetrahedron: Asymmetry

Année:

2011

Langue:

english

Fichier:

PDF, 585 KB

english, 2011

40

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells

Rosa Calvello, Maria Antonietta Panaro, Maria Luigia Carbone, Antonia Cianciulli, Maria Grazia Perrone, Paola Vitale, Paola Malerba, Antonio Scilimati

Journal:

Pharmacological Research

Année:

2012

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2012

41

Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones

Vitale, Paola, D’Introno, Cinzia, Perna, Filippo Maria, Perrone, Maria Grazia, Scilimati, Antonio

Journal:

Tetrahedron: Asymmetry

Année:

2013

Langue:

english

Fichier:

PDF, 396 KB

english, 2013

42

β 3 -Adrenoceptor ligand development history through patent review

Perrone, Maria Grazia, Scilimati, Antonio

Journal:

Expert Opinion on Therapeutic Patents

Année:

2011

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2011

43

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase-1 (COX-1) Inhibitors

Vitale, Paola, Tacconelli, Stefania, Perrone, Maria Grazia, Malerba, Paola, Simone, Laura, Scilimati, Antonio, Lavecchia, Antonio, Dovizio, Melania, Marcantoni, Emanuela, Bruno, Annalisa, Patrignani,

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2013

44

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na + Channels

Franchini, Carlo, Carocci, Alessia, Catalano, Alessia, Cavalluzzi, Maria M., Corbo, Filomena, Lentini, Giovanni, Scilimati, Antonio, Tortorella, Paolo, Camerino, Diana Conte, Luca, Annamaria De

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 162 KB

english, 2003

45

Myogenic effect of SP-1f and SP-1h two novel β3-adrenoceptor (β3-AR) agonists in human colonic circular smooth muscle

Maselli, Maria Antonietta, Trisolini, Piero, Ignazzi, Antonia, Notarnicola, Maria, Lorusso, Dionigi, Pezzolla, Francesco, Iacobazzi, Dominga, Scilimati, Antonio, Perrone, Maria Grazia

Journal:

European Journal of Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 689 KB

english, 2014

46

Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles

Vitale, Paola, Perrone, Maria Grazia, Malerba, Paola, Lavecchia, Antonio, Scilimati, Antonio

Journal:

European Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2014

47

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na + Channels.

Franchini, Carlo, Carocci, Alessia, Catalano, Alessia, Cavalluzzi, Maria M., Corbo, Filomena, Lentini, Giovanni, Scilimati, Antonio, Tortorella, Paolo, Camerino, Diana Conte, De Luca, Annamaria

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 41 KB

english, 2005

48

Synthesis of New 2,6-Prolylxylidide Analogues of Tocainide as Stereoselective Blockers of Voltage-Gated Na + Channels with Increased Potency and Improved Use-Dependent Activity

Franchini, Carlo, Corbo, Filomena, Lentini, Giovanni, Bruno, Gemma, Scilimati, Antonio, Tortorella, Vincenzo, Conte Camerino, Diana, De Luca, Annamaria

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 96 KB

english, 2000

49

Upregulation of β3-Adrenergic Receptor mRNA in Human Colon Cancer: A Preliminary Study

Perrone, Maria Grazia, Notarnicola, Maria, Caruso, Maria Gabriella, Tutino, Valeria, Scilimati, Antonio

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 182 KB

english, 2008

50

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

Perrone, Maria Grazia, Vitale, Paola, Panella, Andrea, Fortuna, Cosimo G., Scilimati, Antonio

Journal:

European Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 2.41 MB

english, 2015